Nicotinamide adenine dinucleotide(NAD+ cas 53-84-9) yog ib qho tseem ceeb coenzyme uas muaj nyob hauv txhua lub hlwb. NAD + yog daim ntawv oxidized ntawm NAD, nqa tus nqi zoo thiab ua lub luag haujlwm tseem ceeb hauv kev ua haujlwm ntawm tes.
Thaum lub sij hawm ua pa ntawm tes, NAD + ua raws li cov khoom siv hluav taws xob: nws txais cov khoom siv hluav taws xob los ntawm cov txheej txheem metabolic thiab txo mus rau NADH. Tom qab ntawd, NADH tso tawm cov hluav taws xob hauv cov kab ua pa mitochondrial thiab oxidized rov qab rau NAD+. Lub voj voog hloov pauv ntawm NAD + thiab NADH yog qhov tseem ceeb rau cellular zog metabolism, thauj electron, thiab ATP synthesis.
Lub luag haujlwm ntawm NAD +
NAD + yog ib qho tseem ceeb ntawm coenzyme hauv cellular zog metabolism. Nws ncaj qha koom rau hauv cov txheej txheem biochemical uas hloov cov as-ham rau hauv lub zog siv tau (ATP) hauv cov hlwb. Nws ua haujlwm zoo li "lub zog catalyst," ua lub luag haujlwm tseem ceeb hauv kev tsim hluav taws xob thiab cellular metabolism.
Thaum DNA cellular puas lawm, piv txwv li los ntawm ultraviolet (UV) hluav taws xob los yog oxidative kev nyuaj siab, ib tug kho cov protein hu ua PARP (poly ADP-ribose polymerase) yuav ua rau hnyav heev. Thaum nws cov txheej txheem kho, PARP siv ntau ntawm NAD + raws li "cov khoom siv raw."
Cov kev tshawb fawb pom tau hais tias raws li cov txheej txheem kev laus zuj zus, NAD + qib hauv lub cev maj mam poob, ua rau muaj qhov tsis xws luag hauv ob qho tib si nuclear thiab mitochondrial muaj nuj nqi. Qhov no tuaj yeem ua rau muaj hnub nyoog ntau yam - cuam tshuam txog kev hloov pauv pathological.
Cov txiaj ntsig tseem ceeb ntawm NAD + Ntxiv rau daim tawv nqaij:
1. Anti-Tshav Kev Laus thiab DNA Kho
UV hluav taws xob activates PARP enzyme, uas ua rau ib tug tseem ceeb depletion ntawm NAD + nyob rau hauv keratinocytes thiab fibroblasts. Kev tuav lossis kho cov qib NAD + tau pom nyob rau hauv cov kev tshawb fawb ntawm tes los txhawb DNA kho cov txheej txheem, pab tiv thaiv UV- cuam tshuam kev puas tsuaj.
2.Anti-Inflammatory and Immune Regulation
Sirtuins, tseem hu ua "ntev cov proteins," yog ib tsev neeg tseem ceeb ntawm cov proteins uas tswj cov metabolism, tiv thaiv kev ntxhov siab, thiab txo qis hauv cov hlwb. NAD + activates sirtuins (tshwj xeeb tshaj yog SIRT1), uas inhibit inflammatory pathways, pab txo qhov liab thiab rhiab heev. Qhov no muaj cov txiaj ntsig zoo hauv kev tawm tsam inflammatory aging.
3.Antioxidant thiab ROS txo
Reactive oxygen hom (ROS) yog cov khoom ntawm oxidative kev nyuaj siab los ntawm UV rays, muaj kuab paug, thiab lwm yam ib puag ncig, ua rau cov tawv nqaij puas. NAD + ua lub luag haujlwm hauv kev tswj cov cell's antioxidant enzyme systems, pab kom tsis txhob muaj ntau tshaj ROS. Qhov no txo cov oxidative kev puas tsuaj rau cell membranes, DNA, thiab cov proteins, yog li qeeb cov txheej txheem kev laus.
Xaus
Raws li cov khoom xyaw kom zoo nkauj, NAD + qhia tau tias muaj peev xwm loj heev vim nws lub luag haujlwm tseem ceeb hauv cellular zog metabolism, kho DNA, tiv thaiv antioxidant, thiab tiv thaiv - txoj hauv kev. Nrog rau kev tshawb fawb tsis tu ncua rau hauv NAD + daim ntawv thov, cov khoom xyaw no tuaj yeem dhau los ua ib feem ntawm kev tu tawv nqaij. Rau cov khoom siv tawv nqaij, kev sib koom ua ke NAD + tuaj yeem muab ntau txoj hauv kev los tsim cov khoom lag luam zoo nrog ntau cov txiaj ntsig ntawm daim tawv nqaij, muab cov neeg siv khoom nrog ntau cov kev kho tawv nqaij.
Tsis lees paub:
Cov ntaub ntawv muab rau hauv lub vev xaib no yog muab los ntawm internet thiab tsis yog npaj raws li cov lus qhia kws kho mob. Peb tsuas yog lub luag haujlwm rau lub koom haum, formatting, thiab kho cov ntawv thiab tsis lav qhov tseeb lossis qhov tseeb ntawm cov ntsiab lus. Thov nrog tus kws kho mob tham ua ntej yuav hloov pauv koj txoj kev npaj khomob lossis ua ib yam dabtsi.
